Wound Healing and Regenerative Medicine Research Program
Director, Marjana Tomic-Canic
The overall goal of our translational, multi-disciplinary program in wound healing is to understand the molecular and cellular mechanisms of tissue repair and regeneration in skin and its pathogenesis, by integrating knowledge at the bench with clinical outcomes at the bedside. Consequential to the extended life span of the human population and increased prevalence of diabetes, we are faced with epidemic proportions of chronic wounds such as diabetic foot ulcers, pressure (bed) ulcers and venous ulcers, which are the leading cause of lower-leg amputations in the elderly, as well as in the diabetic populations.
Our mission is to develop novel approaches to reduce incidence and accelerate wound healing of chronic wounds. This includes identifying which molecular and cellular mechanisms are utilized during normal, acute wound healing process, identifying what molecular events lead to inhibition of wound healing in chronic (non-healing) wounds and further, developing local sustained gene delivery mechanisms for their treatment.
This program integrates research activity of many research laboratories, clinical and research programs. This collaborative approach includes the following Core laboratories:
Ajdic Lab: understanding molecular mechanisms of biofilm formation and its dynamics;
Pastar Lab: mechanisms of host response to wound infection;
Stojadinovic Lab: role of adaptive and innate immunity in wound healing;
Tomic-Canic Lab: mechanism controlling the wound healing process and its molecular pathogensis;
In addition, our efforts integrate collaborations with many laboratories including: Badiavas, Cao Wikranamayake, Davis, Grichnik, Jimenez and Li Laboratories, Clinical Research Program, Wound Pathology Program and many others at the UM.