Tomic-Canic Lab : Publications




Access to the article:

Stone RC, Stojadinovic O, Rosa AM, Ramirez HA, Badiavas E, Blumenberg M, Tomic-Canic M. A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers. Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf8611

Selected publications

1. Eming SA, Tomic-Canic M.:Updates in wound healing: Mechanisms and translation. Exp Dermatol. 2017 Feb;26(2):97-98. Guest Edited the Special Issue

2. Rivka C. Stone, Olivera Stojadinovic, Ashley M. Rosa, Horacio A. Ramirez, Evangelos Badiavas, Miroslav Blumenberg and Marjana Tomic-Canic: Treatment of Venous Leg Ulcers with a Bioengineered Living Cell Construct Reactivates the Acute Wound Healing Response. Science Translational Medicine (2017) Jan 4;9(371)

3. Ivan Jozic, Sasa Vukelic, Olivera Stojadinovic, Horacio A. Ramirez, Marjana Tomic Canic: Membranous Glucocorticoid Receptor Activates PLC/PKC/GSK-3β/β-catenin Pathway to Inhibit Wound Closure. Journal of Investigative Dermatology (2016) S0022-202X(16)32803-2. doi: 10.1016/j.jid.2016.11.036. [Epub ahead of print]

4. Stojadinovic O, Ramirez H, Pastar I, Gordon KA, Stone RC, Choudhary S, Nouri KN, Badiavas E and Tomic-Canic M: MiR-21 and miR-205 are Induced in Invasive Cutaneous Squamous Cell Carcinomas (2017) Archives of Dermatological Research, Mar;309(2):133-139

5. Liang, Liang,Stone, Rivka S, Stojadinovic, Olivera, Ramirez, Horacio, Maione, Anna, Smith, Avi; Yanaz, Vanessa, Veves, Aristides, Kirsner, Robert S, Garlick, Jonathan, omic-Canic, Marjana: Integrative Analysis of miRNA and mRNA Paired Expression Profiling of Primary Fibroblast Derived from Diabetic Foot Ulcers Reveals Multiple Impaired Cellular Functions, (2016) Wound Repair and Regeneration Nov;24(6):943-953. Journal Cover

6. Stone, Rivka; Pastar, Irena; Ojeh, Nkemcho; Chen, Vivien; Liu, Sophia; Garzon, Karen; Tomic-Canic, Marjana: Epithelial-Mesenchymal Transition in Tissue Repair and Fibrosis. Cell and Tissue Repair (2016) Sep;365(3):495-506

7. Linsey E. Lindley, Olivera Stojadinovic, Irena Pastar, and Marjana Tomic-Canic: Biology and Biomarkers for Wound Healing, Plastic and Reconstructive Surgery (2016) Sep;138:18S-28S

8. Anna G. Maione, Liang Liang, Stojadinovic Olivera,Avi Smith, Yanaz V, Elana Bethk, David Mooney, Arisitidis Veves, Marjana Tomic Canic and Jonathan Garlick: Altered ECM Deposition by Diabetic Foot Ulcer-Derived Fibroblasts Implicates Fibronectin in Chronic Wound Repair. (2016) Wound Repair Regeneration, Sep 8. doi: 10.1111/wrr.12470. [Epub ahead of print]

9. Irena Pastar, Olivera Stojadinovic, Rivka C. Stone, Nkemcho Ojeh, Andrew P. Sawaya, Sasa Vukelic, Herbert H. Samuels, MarjanaTomic-Canic: Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress and Migration (2016) Journal Cell Physiology, Nov;231(11):2452-63.

10. McCormack RM, de Armas LR, Shiratsuchi M, Fiorentino DG, Olsson ML, Lichtenheld MG, Morales A, Lyapichev K, Gonzalez LE, Strbo N, Sukumar N, Stojadinovic O, Plano GV, Munson GP, Tomic-Canic M, Kirsner RS, Russell DG, Podack ER: Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. Elife. 2015 Sep 24;4. pii: e06508.

11. Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O: Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications. Int J Mol Sci. (2015) 16(10):25476-501.

12. Ramirez HA, Liang L, Rosa A, Pastar I, Stojadinovic O, Zwick TG, Kirsner RS, Maione A, Garlick J and Tomic-Canic M: Genomic, microRNA and tissue comparative analysis reveals subtle differences between normal and diabetic foot skin. PlosOne (2015) Aug 28;10(8):e0137133

13. Jozic I, Daunert S, Tomic-Canic M, Pastar I. Nanoparticles for Fidgety Cell Movement and Enhanced Wound Healing. J Invest Dermatol. 2015 Sep;135(9):2151-3.

14. Jozic I, Stojadinovic O, Kirsner RS and Tomic-Canic M: Skin Under the (Spot)-Light: Cross talk with the Central Hypothalamic–Pituitary–Adrenal (HPA) Axis. (2015) Journal of Investigative Dermatology. Jun;135(6):1469-71.

15. Maione AG, Brudno Y, Stojadinovic O, Park LK, Smith A, Tellechea A, Leal EC, Kearney CJ, Veves A, Tomic-Canic M, Mooney DJ, Garlick JA: Three-dimensional human tissue models that incorporate diabetic foot ulcer-derived fibroblasts mimic in vivo features of chronic wounds. Tissue Eng. 2015 May;21(5):499-508.

16. Yim E, Kirsner RS, Gailey RS, Mandel DW, Chen SC, Tomic-Canic M.: Effect of Physical Therapy on Wound Healing and Quality of Life in Patients With Venous Leg Ulcers. JAMA Dermatol. (2014) [Epub ahead of print]

17. Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, DiPietro L, Falanga V, Fife C, Gardner S, Grice E, Harmon J, Hazzard WR, High KP, Houghton P, Jacobson N, Kirsner RS, Kovacs EJ, Margolis D, McFarland Horne F, Reed MJ, Sullivan DH, Thom S, Tomic-Canic M, Walston J, Whitney J, Williams J, Zieman S, Schmader K.: Chronic wound repair and healing in older adults: Current status and future research. Wound Repair Regen. (2014) Jan-Feb;23(1):1-13.

18. Eming SA, Martin P, Tomic-Canic M.: Wound repair and regeneration: mechanisms, signaling, and translation. (2014) Science Transl Med Dec 3;6(265):265sr6.

19. Jozic I, Stojadinovic O, Kirsner RS and Tomic-Canic M: Stressing the Steroids in Skin: Paradox or Fine-tuning? Journal of Investigative Dermatology, (2014)134(12):2869-72

20. Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M.: Clinical Application of Growth Factors and Cytokines in Wound Healing. Wound Repair Regen. (2014) Sep-Oct;22(5):569-78

21. Tomic-Canic M, Perez-Perez G-I, Blumenberg M: Cutaneous Microbiome Studies in the Times of Affordable Sequencing, Journal of Dermatologic Science (2014) J Dermatol Sci. 2014 Aug;75(2):82-7

22. Pastar I, Stojadinovic O, Yin N, Ramirez H, Nusbaum A, Sawaya A, Patel SB, Khalid L, Isseroff RR and Tomic-Canic M: Epithelialization in Wound Healing: A Comprehensive review, Advances in Wound Care (2014) Adv Wound Care Jul 1;3(7):445-464.

23. Ojeh N, Stojadinovic O, Pastar I, Sawaya A, Yin N, Tomic-Canic M.: The effects of caffeine on wound healing. Int Wound J. 2014

24. Stojadinovic O, Pastar I, Nusbaum, AG, Vukelic S, Krzyzanowska A and Tomic-Canic M: Deregulation of Epidermal Stem Cells Niche in Non-healing Venous Ulcers. (2014) Wound Repair and Regeneration, Vol 22, Issue 2, 220-227 (journal cover);

25. Baquerizo Nole K, Yim E, Van Driessche F, Davidson JM, Martins-Green M, Sen CK, Tomic-Canic M and Kirsner RS: Wound Research Funding from Alternative Sources of Federal Funds in 2012 Wound Repair and Regeneration, (2014) May-Jun;22(3):295-300.

26. Wikramanayake TC, Stojadinovic O, Tomic-Canic M. :Epidermal Differentiation in Barrier Maintenance and Wound Healing. Adv Wound Care 2014 Mar 1;3(3):272-280

27. Stojadinovic O, Yin N, Lehmann J, Pastar I, Kirsner RS, Tomic-Canic M.: Increased Number of Langerhans Cells in the Epidermis of Diabetic Foot Ulcers Correlates with Healing Outcome. (2013) Immunologic Research, 57(1-3):222-8

28. Rolle CE, Chen J, Pastar I, Cardenas TC, Perez R, Hower S, Ferracci F, Snyder R, Tomic-Canic M, Plano LR. Keratinocytes produce IL-6 in response to desmoglein 1 cleavage by Staphylococcus aureus exfoliative toxin A. (2013) Immunol Res. 57(1-3):258-67

29. Mimoso C, Lee D-D, Zavadil J, Tomic-Canic M and Blumenberg M: Analyses and metaanalyses of transcriptional profiling in human epidermis. Epidermal Stem Cells: Methods and Protocols (2013) 1195:61-97

30. Gordillo GM, Bernatchez SF, Diegelmann R, Di Pietro LA, Eriksson E, Hinz B, Hopf HW, Kirsner R, Liu P, Parnell LK, Sandusky GE, Sen CK, Tomic-Canic M, Volk SW, Baird A.: Preclinical Models of Wound Healing: Is Man the Model? Adv Wound Care (2013) 2(1):1-4.

31. Richmond NA, Lamel SA, Davidson JM, Martins-Green M, Sen CK, Tomic-Canic M, Vivas AC, Braun LR, Kirsner RS. US-National Institutes of Health-funded research for cutaneous wounds in 2012. Wound Repair Regen. (2013) 21(6):789-92.. PMID:24134696

32. Olivera Stojadinovic, Julia Minkiewicz, Andrew Sawaya,Jonathan W. Bourne, Peter Torzilli, Juan Pablo de Rivero Vaccari,W. Dalton Dietrich, Robert W. Keane and Marjana Tomic-Canic: Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load. Plos One, 2013 8(8):e69223.

33. Olivera Stojadinovic, Andrew Sawaya, Irena Pastar and Marjana Tomic-Canic: Glucocorticoid Receptor Localizes to Adherens Junctions at the Plasma Membrane of Keratinocytes, (2013) PLoS One. 2013 Apr 30;8(4):e63453.

34. Olivera Stojadinovic, Jennifer N. Landon, Katherine A. Gordon, Irena Pastar, Julia Escandon, Alejandra Vivas, Andrea D. Maderal, David J. Margolis, Robert S. Kirsner and Marjana Tomic-Canic: Quality assessment of tissue specimens for studies of diabetic foot ulcers. (2013) Experimental Dermatology 22 (3) 216–218

35. Pastar I, Nusbaum AG, Gil J, Patel SB, Chen J, Valdes J, Stojadinovic O, Plano LR,Tomic-Canic M, Davis SC. Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection. PLoS One. 2013;8(2):e56846.

36. Stojadinovic O, Sawaya A, Pastar I and Tomic-Canic M: Glucocorticoid Receptor Localizes to Adherens Junctions at the Plasma Membrane of Keratinocytes, (2013) Plos One in press

37. Olivera Stojadinovic, Jennifer N. Landon, Katherine A. Gordon, Irena Pastar, Julia Escandon, Alejandra Vivas, Andrea D. Maderal, David J. Margolis, Robert S. Kirsner and Marjana Tomic-Canic: Quality assessment of tissue specimens for studies of diabetic foot ulcers. (2013) Experimental Dermatology 22 (3) 216–218

38. Pastar I, Khan AA, Stojadinovic O, Lebrun EA, Medina MC, Brem H, Kirsner RS, Jimenez JJ, Leslie C, Tomic-Canic M.: Induction of specific miRNAs inhibits cutaneous wound healing. J Biol Chem. (2012) 287 (35):29324-35

39. Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M: Cortisol synthesis in epidermis is induced by IL-1 and tissue injury Journal of Biological Chemistry (2011), 286(12):10265-75

40. Stojadinovic O, Ito M, Tomic-Canic M.: Hair cycling and wound healing: to pluck or not to pluck? Journal of Investigative Dermatology (2011) Feb;131(2):292-4.

41. Stojadinovic O, Lebrun E, Pastar I, Kirsner RS, Davis SC, Tomic-Canic M: Statins as Potential Therapeutic Agents for Wound Healing Disorders. Expert Rev Dermatol. (2010) 5(6):689-698.

42. Lebrun E, Tomic-Canic M, Kirsner RS.:The role of surgical debridement in healing of diabetic foot ulcers. Wound Repair Regen. 18(5):433-8 (2010)

43. Pastar I, Stojadinovic O, Krzyzanowska A, Barrientos S, Stuelten C, Zimmerman K, Blumenberg M, Brem H, Tomic-Canic M: Attenuation of TGFß Signaling Pathway in Chronic Venous Ulcers. Molecular Medicine 16(3-4):92-101, (2010)

44. Vukelic S, Stojadinovic O, Pastar I, Vouthounis C, Krzyzanowska A, Das S, Samuels HH, Tomic-Canic M. Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. Journal of Biological Chemistry 285(3):1980-8 (2010). Science has selected this paper as an “Editor Choice” which highlights interesting papers published in journals other than Science ( )

45. Brem, H., Kodra A, Golinko, MS, Entero H, Stojanidovic, O., Wang, V, Ehrlich, HP and Tomic-Canic, M: Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing, Journal of Investigative Dermatology, 129(9):2275-87 (2009)

46. Lee D-D, Stojadinovic O, Krzyzanowska A, Blumenberg M and Tomic-Canic M: Retinoid-Responsive Transcriptional Changes in Epidermal Keratinocytes. Journal of Cellular Physiology, 220(2):427-439 (2009)

47. Brem H, Golinko MS, Stojadinovic O, Kodra A, Diegelmann RF, Vukelic S, Entero H, Coppock DL and Tomic-Canic M: Primary cultured fibroblasts derived from patients with chronic wounds: New cell lines available to the research community, Journal of Translational Medicine, 1;6:75(2008)

48. Charles C.A, Tomic-Canic, M., Vincek V., Nassiri M., Stojadinovic O, Eaglstein W and Kirsner R: A gene signature of non-healing venous ulcers: potential diagnostic markers. Journal of American Academy of Dermatology, Nov;59(5):758-71(2008)

49. Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko MS, Brem H and Tomic-Canic M: Deregulation of Keratinocyte Differentiation and Activation Pathways are a Hallmark of Pathogenesis of chronic wounds, Journal of Cell and Molecular Medicine, Dec;12(6B):2675-90(2008)

50. Pastar I, Stojadinovic O and Tomic-Canic M: The Role of Keratinocytes in Healing of Chronic Wounds Surgical Technology International, 17:105-12, (2008)

51. Harsha A., Stojadinovic O., Brem H., Sehara-Fujisawa A., Wewer U., Loomis CA., Blobel CP and Tomic-Canic M: ADAM12: a Potential Target for the Treatment of Chronic Wounds Journal of Molecular Medicine, 86(8):961-9, (2008)

52. Barrientos S., Stojadinovic, O., Golinko MS, Brem H. and Tomic-Canic M: Growth Factors and Cytokines in Wound Healing, Wound Repair and Regeneration, 16 (5) 585-590, (2008)

53. Marjana Tomic-Canic, Olivera Stojadinovic Brian Lee, Rebecca Walsh and Miroslav Blumenberg: Nexus Between Epidermolysis Bullosa and Transcriptional Regulation by Thyroid Hormone in Epidermal Keratinocytes, Clinical and Translational Science, 1 (1) 45-49, (2008)

54. Brem H and Tomic-Canic M: Cellular and Molecular Basis of Wound Healing in Diabetes Journal of Clinical Investigations, 117:1219-1222, (2007)

55. Blumenberg, M and Tomic-Canic, M: Gene Profiling: Implications in Dermatology Expert Review of Dermatology, 2 (6), 763-768, (2007)

56. Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, and Tomic-Canic M : Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement, Molecular Medicine 13 (1-2) 30-39, (2007)

57. Brem H, Tomic-Canic M , Entero H , Hanflik A, Wang V, Fallon J, Ehrlich HP. The Synergism of age and db/db genotype impairs wound healing. Experimental Gerontology, 42(6):523-31, (2007)

58. Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H and Tomic-Canic M:Novel Genomic Effects of Glucocorticoids in Epidermis: Inhibition of Apoptosis, IFNγ Pathway and Wound Healing along with Promotion of Terminal Differentiation, Journal of Biological Chemistry ,282(6):4021-34,(2007)

59. Tomic-Canic M., Mamber W.S., Stojadinovic O., Lee B., Radoja N. and McMichael J.: Streptolysin O Enhances Keratinocyte Migration and Proliferation and Promotes Skin Organ Culture Wound Healing In Vitro, Wound Repair Regen. 15(1):71-9, (2007)

60. Morasso I. M and Tomic-Canic M.: Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing. Biology of the Cell, 97(3):173-83. Journal cover page, March issue (2005)

61. Stojadinovic O., Vouthounis, C., Brem., H., Lee B., Fallon, J., Stallcup, M and Tomic-Canic, M: The Role of the -catenin and c-myc in Pathogenesis of Cutaneous Wound Healing. American Journal of Pathology, 167(1):59-69, (2005)

62. Jho S.H., Im M.J. Vouthounis, C, Lee, B., Stojadinovic O., Brem, H. Merchant A. and Tomic-Canic, M.: The Book of Opposites: The role of the nuclear receptor co-regulator proteins in negative regulation by retinoic acid and thyroid hormone receptors. Journal of Investigative Dermatology 124(5):1034-43, (2005)

63. Lee, B., Im, M.J., Vouthounis G., Stojadinovic O., Brem H. and Tomic-Canic, M.: From Enhanceosome to Repressosome: Molecular Antagonism between Corticosteroids and EGF that Leads to Inhibition of Wound Healing. Journal of Molecular Biology 4;345(5):1083-97, (2005)


Additional publications

Discovery about the Effects of Glucocorticoids in Wound Closure Could Open Wider Possibilities-

Dr. Marjana Tomic-Canic and lab’s work featured on NIH website

Wound Healing Society Honors UM Dermatology Researchers and Clinicians

Wound Healing Researchers Receive Major Recognition and Win Awards at National Meeting

Wound Healing Overview Stresses Need for More Awareness, Research and Treatments

Marjana Tomic-Canic, Ph.D., Elected to NIH Big Data to Knowledge Multi-Council Working Group

Student Researcher Honored with a Dozen Accolades in Two Years

Researchers Begin to Unlock Mystery of Non-Healing Leg Wounds

Wound Researchers Find Greater Risk for Pressure Ulcers in the Elderly-

Wound Healing Pioneer Appointed to NIH’s Nursing Research Advisory Council

Women in Academic Medicine Celebrating Women’s History Month

UM Researchers Pinpoint Mechanism that Halts Healing of Venous Ulcers, 8.30.2012 News

Tomic-Canic explores science of wound healing , NIH Record, April 13, 2012

Marjana Tomic-Canic, Ph.D., Presents NIH’s Weekly Lecture 3.27.2012.

Wound Healing Society, Board of Directors

Chronic Questions. Feature story and Cover, Medicine Magazine Vol 12 (3) 2011

ARRA Apparent, feature story in Medicine Magazine, vol 12, No1, Spring Issue 2010

Transforming Patient Care through Science and Technology: Working Together to Heal Tissue, Horizon pp 4-16, Spring 2007

Helping the Body Heal Itself: New Program Advances Research in Tissue Engineering pp 2-6, Discovery to Recovery, 2006

Press release: June 25 2005 -Researchers Shed New Light on Cause of Bedsores and Other Chronic Wounds

PubMed link for list of references

PubMed references